WNT3A promotes neuronal regeneration upon traumatic brain injury

Chu Yuan Chang, Min Zong Liang, Ching Chih Wu, Pei Yuan Huang, Hong I. Chen, Shaw Fang Yet, Jin Wu Tsai, Cheng Fu Kao, Linyi Chen*

*此作品的通信作者

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

The treatment of traumatic brain injury (TBI) remains a challenge due to limited knowledge about the mechanisms underlying neuronal regeneration. This current study compared the expression of WNT genes during regeneration of injured cortical neurons. Recombinant WNT3A showed positive effect in promoting neuronal regeneration via in vitro, ex vivo, and in vivo TBI models. Intranasal administration of WNT3A protein to TBI mice increased the number of NeuN+ neurons without affecting GFAP+ glial cells, compared to control mice, as well as retained motor function based on functional behavior analysis. Our findings demonstrated that WNT3A, 8A, 9B, and 10A promote regeneration of injured cortical neurons. Among these WNTs, WNT3A showed the most promising regenerative potential in vivo, ex vivo, and in vitro.

原文English
文章編號1463
期刊International Journal Of Molecular Sciences
21
發行號4
DOIs
出版狀態Published - 2 2月 2020

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