Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration

Chia Yu Wang, Dewi Sartika, Ding Han Wang, Po Da Hong, Juin Hong Cherng, Shu Jen Chang, Cheng Che Liu, Yi Wen Wang*, Sheng Tang Wu

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

This article presents an inexpensive method to fabricate gelatin, as a natural polymer, into monofilament fibers or other appropriate forms. Through the wet spinning method, gelatin fibers are produced by smooth extrusion in a suitable coagulation medium. To increase the functional surface of these gelatin fibers and their ability to mimic the features of tissues, gelatin can be molded into a tube form by referring to this concept. Examined by in vitro and in vivo tests, the gelatin tubes demonstrate a great potential for application in tissue engineering. Acting as a suitable filling gap material, gelatin tubes can be used to substitute the tissue in the damaged area (e.g., in the nervous or cardiovascular system), as well as to promote regeneration by providing a direct replacement of stem cells and neural circuitry. This protocol provides a detailed procedure for creating a biomaterial based on a natural polymer, and its implementation is expected to greatly benefit the development of correlative natural polymers, which help to realize tissue regeneration strategies.

原文English
文章編號e58932
期刊Journal of Visualized Experiments
2019
發行號145
DOIs
出版狀態Published - 3月 2019

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