Volume-oriented sample preparation for reactant minimization on flow-based microfluidic biochips with multi-segment mixers

Chi Mei Huang, Chia Hung Liu, Juinn-Dar Huang

    研究成果: Conference contribution同行評審

    23 引文 斯高帕斯(Scopus)

    摘要

    Sample preparation is one of essential processes in most biochemical reactions. In this process, raw reactants are diluted to achieve given target concentrations. So far, most of existing sample preparation techniques only consider mixing of two source solutions under the (1:1) mixing model. In this paper, we propose the first sample preparation algorithm VOSPA that not only blends several (≥ 2) solutions in a dilution operation but also allows various mixing models on flow-based microfluidic biochips with multi-segment mixers. VOSPA is a volume-oriented sample preparation algorithm that enables segment-based intermediate solution reuse for better reactant minimization. Experimental results show that VOSPA can lower the reactant consumption and operation count by 72% and 59% as compared to the baseline bit-scanning method if an 8-segment mixer is used. Moreover, VOSPA outperforms an optimal algorithm, which merely allows the use of (1:1) mixing model; the reactant usage and operation count can be further reduced by 37% and 76%.

    原文English
    主出版物標題Proceedings of the 2015 Design, Automation and Test in Europe Conference and Exhibition, DATE 2015
    發行者Institute of Electrical and Electronics Engineers Inc.
    頁面1114-1119
    頁數6
    ISBN(電子)9783981537048
    出版狀態Published - 22 4月 2015
    事件2015 Design, Automation and Test in Europe Conference and Exhibition, DATE 2015 - Grenoble, France
    持續時間: 9 3月 201513 3月 2015

    出版系列

    名字Proceedings -Design, Automation and Test in Europe, DATE
    2015-April
    ISSN(列印)1530-1591

    Conference

    Conference2015 Design, Automation and Test in Europe Conference and Exhibition, DATE 2015
    國家/地區France
    城市Grenoble
    期間9/03/1513/03/15

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