Viral channel forming proteins - How to assemble and depolarize lipid membranes in silico

Wolfgang B. Fischer*, Monoj Mon Kalita, Dieter Heermann

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Viral channel forming proteins (VCPs) have been discovered in the late 70s and are found in many viruses to date. Usually they are small and have to assemble to form channels which depolarize the lipid membrane of the host cells. Structural information is just about to emerge for just some of them. Thus, computational methods play a pivotal role in generating plausible structures which can be used in the drug development process. In this review the accumulation of structural data is introduced from a historical perspective. Computational performances and their predictive power are reported guided by biological questions such as the assembly, mechanism of function and drug-protein interaction of VCPs. An outlook of how coarse grained simulations can contribute to yet unexplored issues of these proteins is given. This article is part of a Special Issue entitled: Membrane Proteins edited by J.C. Gumbart and Sergei Noskov.

原文English
頁(從 - 到)1710-1721
頁數12
期刊Biochimica et Biophysica Acta - Biomembranes
1858
發行號7
DOIs
出版狀態Published - 1 7月 2016

指紋

深入研究「Viral channel forming proteins - How to assemble and depolarize lipid membranes in silico」主題。共同形成了獨特的指紋。

引用此