Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction

Yun Ting Chao, Tzu Yi Hong, Ching Ju Yang, Jen Chuen Hsieh*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional engagement of semantic memory system within the olfactory network, in an allele dosage-dependent manner. This suggests that the Met allele may promote adaptive neural reorganization to augment olfactory capacity.

原文English
文章編號20007
期刊Scientific reports
12
發行號1
DOIs
出版狀態Published - 12月 2022

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