Validation of carotid artery tonometry as a means of estimating augmentation index of ascending aortic pressure

Chen Huan Chen, Chih Tai Ting, Amit Nussbacher, Erez Nevo, David A. Kass, Peter Pak, Shih Pu Wang, Mau Song Chang, Frank C.P. Yin*

*此作品的通信作者

研究成果: Article同行評審

339 引文 斯高帕斯(Scopus)

摘要

Our objective was to validate a carotid artery tonometry- derived augmentation index as a means to estimate augmentation index (AI) of ascending aortic pressure under various physiological conditions. A total of 66 patients (50 men, 16 women; mean age, 55 years; range, 21 to 78 years, 44 in Taiwan and 22 in the United States) undergoing diagnostic catheterization were studied. Arterial pressure contours were obtained simultaneously from the right common carotid artery by applanation tonometry with an external micromanometer-tipped probe and from the ascending aorta by a micromanometer-tipped catheter at baseline (n=62), after handgrip (n=36), or after sublingual nitroglycerin administration (n=17). The AI (expressed as percentage values) was calculated as the ratio of amplitude of the pressure wave above its systolic shoulder to the total pulse pressure. The carotid AI was consistently lower than the aortic AI, but the two were highly correlated at baseline and after both handgrip and nitroglycerin. Mean±SD and correlation coefficients were baseline (14±16, 28. ± 17, :77), handgrip (18 ± 19, 32. ± 15, 86), and nitroglycerin (7 ± 12, 18. ± 13, .52). In addition, after adjusting for age, sex, height, blood pressure, heart rate, and study site, the changes of both AIs from baseline values with handgrip or nitroglycerin were highly associated such that the aortic AI could be approximated from the carotid AI with appropriate regression equations. The high correlations and predictable changes after intervensions between the central AI and those estimated from noninvasive carotid tonometry suggest that this technique may have wide applicability for many cardiovascular studies.

原文English
頁(從 - 到)168-175
頁數8
期刊Hypertension
27
發行號2
DOIs
出版狀態Published - 1996

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