Tumor targeting with DGEA peptide ligands: A new aromatic peptide amphiphile for imaging cancers

Fu Kai Zhan; Jyun Cheng Liu; Bill Cheng; Yen Chu Liu; Tsung Sheng Lai; Hsin-Chieh Lin; Mei Yu Yeh

doi:10.1039/c8cc08679f

Tumor targeting with DGEA peptide ligands: A new aromatic peptide amphiphile for imaging cancers

Fu Kai Zhan, Jyun Cheng Liu, Bill Cheng, Yen Chu Liu, Tsung Sheng Lai, Hsin-Chieh Lin^*, Mei Yu Yeh

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材料科學與工程學系

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23 引文斯高帕斯（Scopus）

摘要

We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.

原文	English
頁（從 - 到）	1060-1063
頁數	4
期刊	Chemical Communications
卷	55
發行號	8
DOIs	https://doi.org/10.1039/c8cc08679f
出版狀態	Published - 2019

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title = "Tumor targeting with DGEA peptide ligands: A new aromatic peptide amphiphile for imaging cancers",

abstract = "We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.",

author = "Zhan, {Fu Kai} and Liu, {Jyun Cheng} and Bill Cheng and Liu, {Yen Chu} and Lai, {Tsung Sheng} and Hsin-Chieh Lin and Yeh, {Mei Yu}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c8cc08679f",

language = "English",

volume = "55",

pages = "1060--1063",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Tumor targeting with DGEA peptide ligands

T2 - A new aromatic peptide amphiphile for imaging cancers

AU - Zhan, Fu Kai

AU - Liu, Jyun Cheng

AU - Cheng, Bill

AU - Liu, Yen Chu

AU - Lai, Tsung Sheng

AU - Lin, Hsin-Chieh

AU - Yeh, Mei Yu

PY - 2019

Y1 - 2019

N2 - We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.

AB - We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.

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U2 - 10.1039/c8cc08679f

DO - 10.1039/c8cc08679f

M3 - Article

C2 - 30617356

AN - SCOPUS:85060235721

SN - 1359-7345

VL - 55

SP - 1060

EP - 1063

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Tumor targeting with DGEA peptide ligands: A new aromatic peptide amphiphile for imaging cancers

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