Treatment selection for tonsillar squamous cell carcinoma

Yao Yuan Kuo, Pen Yuan Chu, Shyue Yih Chang, Yi Fen Wang, Tung Lung Tsai, Muh Hwa Yang, Ling Wei Wang, Shyh Kuan Tai*


研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)


Background: The optimal treatment for tonsillar squamous cell carcinoma (SCC) remains controversial. The purpose of this study was to evaluate long-term treatment outcomes of patients with tonsillar SCC, in order to aid in appropriate treatment selection. Methods: We conducted a retrospective chart review of 105 patients with curatively treated tonsillar SCC between January 1996 and December 2005. Forty-three patients (41.0%) underwent primary surgery with or without adjuvant therapy (primary surgery group), and 62 patients (59.0%) were treated with radiotherapy/chemoradiotherapy (RT/CRT, organ preservation group). Twenty patients (19%) received tumor tonsillectomy before definitive RT/CRT and were grouped into the organ preservation group. Results: No significant differences were observed between the primary surgery and organ preservation groups in terms of local control (. p = 0.212), regional control (. p = 0.684), distant metastasis (. p = 0.627), 5-year disease-specific survival (DSS, p = 0.774), and overall survival rates (OS, p = 0.667). The rates of major complication (. p = 0.216), long-term dependency on feeding tubes (. p = 0.876), and tracheostomy (. p = 0.401) were also similar. Advanced T classification (T3-4) was the only factor associated with significantly worse DSS (. p = 0.007) and OS (. p = 0.012). However, there was also no difference in final treatment outcomes in T3-4 patients regardless of whether they were treated with primary surgery or RT/CRT. In the organ preservation group, tumor tonsillectomy before RT/CRT did not improve local control (. p = 0.520) or other treatment outcomes, including 5-year DSS (. p = 0.707) and OS (. p = 0.745). Conclusion: Both primary surgery and RT/CRT organ preservation are effective treatments for tonsillar SCC. Single modality treatment, either surgery or RT/CRT, can typically be provided for stage I-II diseases. Although RT/CRT organ preservation is used more frequently for stage III-IV tonsillar SCC in recent years, primary surgery combined with adjuvant therapy still achieves equivalent outcomes. Multidisciplinary pretreatment counseling and the facilities and personnel available are therefore important for decision-making. In addition, if RT/CRT organ preservation is selected as the primary treatment, tumor tonsillectomy is not indicated.

頁(從 - 到)211-217
期刊Journal of the Chinese Medical Association
出版狀態Published - 4月 2013


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