Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury

Li Fang Chou, Chih Wei Huang, Huang Yu Yang, Ya Chung Tian, Ming Yang Chang, Cheng Chieh Hung, Kuan Hsing Chen, Shen Hsing Hsu, Chung Ying Tsai, Yi Ching Ko, Ting Wen Chen*, Chih Wei Yang*

*此作品的通信作者

研究成果: Article同行評審

摘要

Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with adenine-induced and chronically Leptospira-infected kidneys were analysed. Chronic inflammation and T-helper 17 immune responses were activated and a high-level expression of Indoleamine 2,3-dioxygenase 1 protein was found. The results indicate that the combination may predispose patients to chronic inflammation, kidney function disruption, and symptoms seen in progressive chronic kidney disease (CKD). Furthermore, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. This study identified several significantly disrupted genes that could serve as potential targets for the diagnosis or treatment of CKD. Our work provides insight into the combined effect of leptospirosis and secondary kidney damage and the molecular basis for rapid progression of CKD.

原文English
文章編號110624
期刊Genomics
115
發行號3
DOIs
出版狀態Published - 5月 2023

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