Thy-1 is a component common to multiple populations of synaptic vesicles

Chung Jiuan Jeng, Steven A. McCarroll, Thomas F.J. Martin, Erik Floor, James Adams, David Krantz, Stefan Butz, Robert Edwards, Erik S. Schweitzer*

*此作品的通信作者

研究成果: Article同行評審

49 引文 斯高帕斯(Scopus)

摘要

Thy-1, a glycosylphosphatidylinositol-linked integral membrane protein of the immunoglobulin superfamily, is a component of both large dense-core and small clear vesicles in PC12 cells. A majority of this protein, formerly recognized only on the plasma membrane of neurons, is localized to regulated secretory vesicles. Thy-1 is also present in synaptic vesicles in rat central nervous system. Experiments on permeabilized PC12 cells demonstrate that antibodies against Thy-1 inhibit the regulated release of neurotransmitter; this inhibition appears to be independent of any effect on the Ca2+ channel. These findings suggest Thy-1 is an integral component of many types of regulated secretory vesicles, and plays an important role in the regulated vesicular release of neurotransmitter at the synapse.

原文English
頁(從 - 到)685-698
頁數14
期刊Journal of Cell Biology
140
發行號3
DOIs
出版狀態Published - 9 2月 1998

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