Three-Dimensional Fluorescence Diffuse Optical Tomography Using the Adaptive Spatial Prior Approach

Pei An Lo, Huihua Kenny Chiang*

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Purpose: Traditionally, the reconstruction of fluorescence diffuse optical tomography (FDOT) images requires anatomical images as prior information. To integrate anatomical information about tumors or soft tissues into FDOT, additional equipment and procedures are required, involving co-registration, contrast-agent injection, and alignment. Methods: Herein, we propose the adaptive spatial prior approach for reconstructing FDOT images, implemented by using an initial guess of the tumor size and location for single and multi-tumor cases. This technique is most appropriately used when FDOT is combined with limited structural information or a different structural imaging system. This method iteratively modifies the location starting from the estimated location. Results: We conduct simulations, phantom experiments and experiments on meat tissue using the adaptive spatial prior method. Conclusions: The results of these studies demonstrate the feasibility of the adaptive spatial prior approach for FDOT imaging.

原文English
頁(從 - 到)827-834
頁數8
期刊Journal of Medical and Biological Engineering
39
發行號6
DOIs
出版狀態Published - 1 12月 2019

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