Therapeutic time window for rt-PA thrombolysis in a rat photothrombotic ischemic stroke model

Aishwarya Bandla, Ji Min Ling, Yu Hang Liu, Hsin Yi Lai, You Yin Chen, Nitish V. Thakor, Lun De Liao*

*此作品的通信作者

研究成果: Conference contribution同行評審

1 引文 斯高帕斯(Scopus)

摘要

The narrow 3h therapeutic time window for recombinant tissue-type plasminogen activator (rt-PA) thrombolysis is a challenging limitation in acute ischemic stroke treatment. Intense research focus is being laid on developing novel therapeutic interventions for extending the thrombolysis time window using animal stroke models. However, these animal models are anatomically and physiologically different. Here, we assess the effective time window of rt-PA thrombolysis in the photothrombotic ischemic (PTI) stroke model using the electrocorticography (ECoG) system and histology study. Our results indicate that rt-PA provides effective thrombolysis when administered in the initial 1 to 3 hours post-ischemia, beyond which it does not facilitate recovery. This complements the FDA-approved rt-PA time window in humans. However, it is interesting to note that the trend of neural activity did not strictly correspond to infarct volume changes, indicating the importance of multimodal imaging for holistic assessment of therapeutic efficacy. Therefore, in the future, this ECoG setup will be integrated with the functional photoacoustic microscopy (fPAM) system to jointly evaluate neural activity and cerebral hemodynamics to probe neurovascular function changes effective with thrombolysis.

原文English
主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
發行者Springer Verlag
頁面231-234
頁數4
ISBN(電子)9783319122618
DOIs
出版狀態Published - 2015
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 9 10月 201412 10月 2014

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737
ISSN(電子)1433-9277

Conference

Conference1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家/地區Taiwan
城市Tainan
期間9/10/1412/10/14

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