TY - JOUR
T1 - The ventilatory abnormalities and prognostic values of H2FPEF score in dyspnoeic patients with preserved left ventricle systolic function
AU - Huang, Wei Ming
AU - Cheng, Hao Min
AU - Yu, Wen Chung
AU - Guo, Chao Yu
AU - Chiang, Chern En
AU - Chen, Chen Huan
AU - Sung, Shih Hsien
N1 - Publisher Copyright:
© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Aims: Heart failure with preserved ejection fraction (HFpEF) is one of the major diagnoses in dyspnoeic subjects, and H2FPEF score enables robust differentiation of HFpEF. Given ventilatory abnormalities prevail in subjects with HFpEF, the associations between H2FPEF score and pulmonary function remain to be elucidated. Methods and results: Subjects who presented with exertional dyspnoea and had left ventricular ejection fraction of >50% were eligible for this study. Total lung capacity, forced expiratory volume in the 1 s, and forced vital capacity (FVC) were obtained by pulmonary function tests. Pulmonary artery systolic pressure (PASP), the ratio of early ventricular filling flow velocity to the septal mitral annulus tissue velocity (E/e'), and left ventricular mass (LVM) were measured by echocardiogram. Among a total of 5849 participants (65.6 ± 6.4 years, 54% men), 2453 (41.9%) had low H2FPEF score (0 ~ 1) and 160 (2.7%) had high H2FPEF score,6~9 respectively. Subjects with high H2FPEF score were older and had higher proportion of restrictive and obstructive defect, more morbidities, poorer renal function, lower haemoglobin, higher LVM, E/e' ratio, and PASP. During a mean follow-up duration of 30.0 ± 20.5 months, the H2FPEF score was significantly associated with mortality [hazard ratio and 95% confidence intervals, 1.063(1.010–1.18)], independent of sex, haemoglobin, renal function, LVM, and comorbidities. Conclusions: Either obstructive or restrictive ventilation defects prevail in subjects with high H2FPEF score, indicating chronic obstructive pulmonary disease (COPD) is commonly associated with HFpEF. In addition, H2FPEF score was correlated with long-term survival in dyspnoeic subjects with or without concomitant diseases of HFpEF and COPD.
AB - Aims: Heart failure with preserved ejection fraction (HFpEF) is one of the major diagnoses in dyspnoeic subjects, and H2FPEF score enables robust differentiation of HFpEF. Given ventilatory abnormalities prevail in subjects with HFpEF, the associations between H2FPEF score and pulmonary function remain to be elucidated. Methods and results: Subjects who presented with exertional dyspnoea and had left ventricular ejection fraction of >50% were eligible for this study. Total lung capacity, forced expiratory volume in the 1 s, and forced vital capacity (FVC) were obtained by pulmonary function tests. Pulmonary artery systolic pressure (PASP), the ratio of early ventricular filling flow velocity to the septal mitral annulus tissue velocity (E/e'), and left ventricular mass (LVM) were measured by echocardiogram. Among a total of 5849 participants (65.6 ± 6.4 years, 54% men), 2453 (41.9%) had low H2FPEF score (0 ~ 1) and 160 (2.7%) had high H2FPEF score,6~9 respectively. Subjects with high H2FPEF score were older and had higher proportion of restrictive and obstructive defect, more morbidities, poorer renal function, lower haemoglobin, higher LVM, E/e' ratio, and PASP. During a mean follow-up duration of 30.0 ± 20.5 months, the H2FPEF score was significantly associated with mortality [hazard ratio and 95% confidence intervals, 1.063(1.010–1.18)], independent of sex, haemoglobin, renal function, LVM, and comorbidities. Conclusions: Either obstructive or restrictive ventilation defects prevail in subjects with high H2FPEF score, indicating chronic obstructive pulmonary disease (COPD) is commonly associated with HFpEF. In addition, H2FPEF score was correlated with long-term survival in dyspnoeic subjects with or without concomitant diseases of HFpEF and COPD.
KW - Heart failure with preserved ejection fraction
KW - Mortality
KW - Pulmonary function
UR - http://www.scopus.com/inward/record.url?scp=85085699460&partnerID=8YFLogxK
U2 - 10.1002/ehf2.12754
DO - 10.1002/ehf2.12754
M3 - Article
C2 - 32488965
AN - SCOPUS:85085699460
SN - 2055-5822
VL - 7
SP - 1872
EP - 1879
JO - ESC Heart Failure
JF - ESC Heart Failure
IS - 4
ER -