摘要
Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
原文 | English |
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頁(從 - 到) | 193-199 |
頁數 | 7 |
期刊 | Journal of Biomedical Science |
卷 | 13 |
發行號 | 2 |
DOIs | |
出版狀態 | Published - 3月 2006 |