The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

Shan Yen Chou*, Su San Chen, Chin Chung Ho, Shiang Ling Huang, Tsai Mien Huang, Ohm Guo Pan, Chia Lin Wang, Ying Chen, Hsiao Hwa Lu, Shih Hwa Liu, Shir Ly Huang, Ren Shou Chiang

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole analogs of imidazole angiotensin II antagonist, DuP 753, are reported. 5-Butyl-3-[(2-trifluoromethyl)phenyl]-2,1,3,4-1H-thiatriazole-2-one biphenyltetrazole (63) is found to have good in vitro activity.

原文English
頁(從 - 到)83-93
頁數11
期刊Journal of the Chinese Chemical Society
43
發行號1
DOIs
出版狀態Published - 1996

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