The role of smoothened in cancer

Kuo Shyang Jeng, I. Shyan Sheen, Chuen Miin Leu, Ping Hui Tseng*, Chiung Fang Chang


研究成果: Review article同行評審

34 引文 斯高帕斯(Scopus)


Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.

頁(從 - 到)1-20
期刊International Journal Of Molecular Sciences
出版狀態Published - 2 9月 2020


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