The role of chemokines and chemokine receptors in diabetic nephropathy

Ting Ting Chang, Jaw Wen Chen*

*此作品的通信作者

研究成果: Review article同行評審

24 引文 斯高帕斯(Scopus)

摘要

Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN.

原文English
文章編號3172
期刊International Journal Of Molecular Sciences
21
發行號9
DOIs
出版狀態Published - 1 5月 2020

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