The role of apoptosis in the development and function of T lymphocytes

Nu Zhang, Heather Hartig, Ivan Dzhagalov, David Draper, You Wen He*

*此作品的通信作者

研究成果: Review article同行評審

126 引文 斯高帕斯(Scopus)

摘要

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.

原文English
頁(從 - 到)749-769
頁數21
期刊Cell Research
15
發行號10
DOIs
出版狀態Published - 2005

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