Previous literature has suggested that consciousness of patients in vegetative state (VS) may be enhanced via music listening; however, studies empirically documenting the link among music, vegetative state, and electrocardiogram (ECG) are scant. Therefore, the current article attempts to explore how music improves the VS patient's condition with the assessment of ECG recordings. The present work involved a follow-up of case report, consisting of forty-two 150-min sessions, whose duration is longer than other VS studies. The quantitative analysis of the data was conducted through C programming language, HRV Analysis, EXCEL and MATLAB package software in order to find a specific pattern of HRV. Results of the study showed a medium level of consistence between the two variables of music and ECG. To conclude, this publication may be of importance in presenting some specific pattern of the ECG diagram while letting VS patients listen to the music.