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The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons
Yi Heng Hsieh
, A. Ching Chao
, Yi Chun Lin
, Shang Der Chen
,
Ding I. Yang
*
*
此作品的通信作者
腦科學研究所
腦科學研究中心
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11
引文 斯高帕斯(Scopus)
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Keyphrases
Nuclear factor-κB
100%
Antioxidant System
100%
Amyloid-β Peptide
100%
Sestrin2
100%
Pifithrin-α
37%
Reactive Oxygen Species Production
25%
Small Interfering RNA (siRNA)
25%
Nuclear Translocation
25%
Short Hairpin RNA (shRNA)
25%
8-hydroxydeoxyguanosine (8-OHdG)
25%
Transcription Factor
12%
Molecular Mechanism
12%
Overexpression
12%
P53 Inhibitor
12%
Targeted Sequencing
12%
Gene Promoter
12%
Alzheimer's Disease
12%
Lipid Peroxidation
12%
Autophagy
12%
Induced Production
12%
Induced Expression
12%
Antioxidative Effect
12%
P53 Activity
12%
C-terminal Fragments
12%
Antioxidation
12%
Neuroprotective Effect
12%
Senile Plaques
12%
Rat Cortical Neurons
12%
Antioxidant Effect
12%
Autophagy Regulation
12%
SN50
12%
Neuroscience
P53
100%
Amyloid Beta Protein
100%
Nuclear Factor
37%
Reactive Oxygen Species
25%
Promoter Region
25%
Autophagy
25%
Small Interfering RNA
25%
Small Hairpin RNA
25%
Amino Terminal Sequence
12%
Transcription Factors
12%
Alzheimer's Disease
12%
Antioxidant
12%
C-Terminus
12%
Neuroprotective Agent
12%
8 Hydroxydeoxyguanosine
12%
Lipid Peroxidation
12%
Senile Plaque
12%
Sn 50
12%
Biochemistry, Genetics and Molecular Biology
P53
100%
Amyloid Beta
100%
Beta-Peptide
100%
Small Interfering RNA
25%
Small Hairpin RNA
25%
Autophagy
25%
N-Terminus
12%
C-Terminus
12%
Promoter Region
12%
Transcription Factors
12%
Gene Promoter
12%
Lipid Peroxidation
12%
Senile Plaque
12%
Deoxyguanosine
12%