The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients

Hung Hsin Lin, Hsueh Li Yang, Jen Kou Lin, Chun Chi Lin, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Yuan Tzu Lan, Tzu Chen Lin, Wei Shone Chen, Wen Yih Liang, Shih Ching Chang

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)


BACKGROUND/AIMS: We evaluated the prognostic significance of clinicopathologic features recommended by the majority of guidelines for identifying high-risk stage it colon cancer patients.

METHODOLOGY: We enrolled 665 stage II colorectal cancer patients at Taipei Veterans General Hospital in 2002-2006. Patients who received preoperative or postoperative chemotherapy were excluded (124). The measured endpoint was disease-free survival.

RESULTS: Of 541 patients, 59 showed stage T4 tumors; 35, lymphovascular invasion; 19, poor differentiation, and 251, carcinoembryonic antigen levels of > 5 ng/mL; 53 underwent emergent operations. Colorectal cancer recurred in 84 patients. The 5-year disease-free survival rate was 84.5%. Univariate and multivariate analyses revealed 3 independent factors affecting the prognosis significantly tumor stage T4, high carcinoembryonic antigen level, and presence of lymphovascular invasion. Considering the cumulative effect of risk factors, the 5-year disease-free survival rate of patients with tumors without any risk factor was 90.2%, which was significantly better than that of patients with 1 or 2 risk factors (82.3%, 61.6%).

CONCLUSIONS: Stage II colorectal cancer patients had excellent outcome. Ad juvant chemotherapy may be warranted for patients with multiple risk factors.

頁(從 - 到)1024-1027
出版狀態Published - 1 6月 2014


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