The Nazarov Cyclization

F. G. West*, O. Scadeng, Yen-Ku Wu, R. J. Fradette, S. Joy

*此作品的通信作者

研究成果: Chapter同行評審

47 引文 斯高帕斯(Scopus)

摘要

Although well established as a reliable method for forming new cyclopentenone rings from acyclic precursors, the Nazarov reaction has been the subject of substantial recent work. The effect of substituents on 1,4-dien-3-one precursors is discussed. Asymmetric methods are presented, including chirality transfer, chiral Lewis acids, and asymmetric organocatalysis. An overview is given of various 'interrupted' variants, in which cyclized intermediates undergo domino trapping reactions with either nucleophilic or electrophilic reagents. Finally, cyclization via alternative and unconventional precursors is described, including the vinylogous and iso-Nazarov reactions, transition metal activation of alkyne-containing substrates, and the aza-Nazarov reaction.

原文English
主出版物標題Comprehensive Organic Synthesis
主出版物子標題Second Edition
發行者Elsevier Ltd
頁面827-866
頁數40
5
ISBN(列印)9780080977430
DOIs
出版狀態Published - 1 二月 2014

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