The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration

Chih Chiang Chen, Maksim V. Plikus, Pin Chi Tang, Randall B. Widelitz, Cheng Ming Chuong*

*此作品的通信作者

研究成果: Review article同行評審

65 引文 斯高帕斯(Scopus)

摘要

Hair and feathers are unique because (1) their stem cells are contained within a follicle structure, (2) they undergo cyclic regeneration repetitively throughout life, (3) regeneration occurs physiologically in healthy individuals and (4) regeneration is also induced in responsee-adjacent micro-environmental niche, this niche is also modulated dynamically by extra-follicular macro-environmental signals, allowing stem cells to adapt to a larger changing environment and physiological needs. Here we review several examples of macro-environments that communicate with the follicles: intradermal adipose tissue, innate immune system, sex hormones, aging, circadian rhythm and seasonal rhythms. Related diseases are also discussed. Unveiling the mechanisms of how stem cell niches are modulated provides clues for regenerative medicine. Given that stem cells are hard to manipulate, focusing translational therapeutic applications at the environments appears to be a more practical approach.

原文English
頁(從 - 到)1423-1440
頁數18
期刊Journal of Molecular Biology
428
發行號7
DOIs
出版狀態Published - 10 4月 2016

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