TY - GEN
T1 - The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures
AU - Chen, Chieh
AU - Tsai, Cheng Yu
AU - Cheng, Yu Ting
AU - Tsai, Hsiao En
AU - Lo, Yung Chieh
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.
AB - In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.
KW - Troponin T
KW - anodic aluminum oxide
KW - methylene-blue
KW - molecularly imprinted polymer
KW - nanocomposite structure
KW - urine testing
UR - http://www.scopus.com/inward/record.url?scp=85186730738&partnerID=8YFLogxK
U2 - 10.1109/MEMS58180.2024.10439402
DO - 10.1109/MEMS58180.2024.10439402
M3 - Conference contribution
AN - SCOPUS:85186730738
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 312
EP - 315
BT - IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024
Y2 - 21 January 2024 through 25 January 2024
ER -
