TY - JOUR
T1 - The impact of phthalate on reproductive function in women with endometriosis
AU - Chou, Ya-Ching
AU - Tzeng, Chii Ruey
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology (grant number 104‐2314‐B‐038‐063‐MY2, grant number 106‐2314‐B‐038‐072, grant number 107‐2314‐B‐038‐006), Academia Sinica (grant number BM10501010036, grant number BM10601010024, grant number BM10701010027), National Health Research Institute (grant number MG‐105‐SP‐07, grant number MG‐106‐SP‐07, grant number MG‐107‐SP‐07; CRT), and Ministry of Science and Technology (grant number 107‐2314‐B‐009‐006; YCC). This work was also supported by the Center for Intelligent Drug Systems and Smart Bio‐devices (IDSB) from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. The figures were created with Biorender.com. 2
PY - 2021/4/5
Y1 - 2021/4/5
N2 - Background: Endometriosis is a common gynecological condition in which stromal or glandular epithelium is implanted in extrauterine locations. Endometriosis causes detrimental effects on the granulosa cells, and phthalate interferes with the biological and reproductive function of endometrial cells at a molecular level. Methods: This article retrospectively reviewed the studies on phthalate exposure and its relationship with endometriosis. A literature search was performed for scientific articles using the keywords “phthalate and endometriosis,” “endometriosis and granulosa cells,” “phthalate and granulosa cells,” and “phthalates and endometrial cells.”. Results: Endometriosis can affect cytokine production, steroidogenesis, cell cycle progression, expression of estrogen receptor-α (ER-α)/progesterone receptor (PR), and cause endoplasmic reticulum stress, senescence, apoptosis, autophagy, and oxidative stress in the granulosa cells. Mono-n-butyl phthalate (MnBP) alters the expression of cytokines, cell cycle-associated genes, ovarian stimulation, steroidogenesis, and progesterone production. Several in vitro studies have demonstrated that phthalate caused inflammation, invasion, change in cytokines, increased oxidative stress, viability, resistance to hydrogen peroxide, and proliferation of endometrial cells. Conclusion: This might provide new insights about the impact of phthalate on the pathogenesis of endometriosis and its consequences on the ovarian function.
AB - Background: Endometriosis is a common gynecological condition in which stromal or glandular epithelium is implanted in extrauterine locations. Endometriosis causes detrimental effects on the granulosa cells, and phthalate interferes with the biological and reproductive function of endometrial cells at a molecular level. Methods: This article retrospectively reviewed the studies on phthalate exposure and its relationship with endometriosis. A literature search was performed for scientific articles using the keywords “phthalate and endometriosis,” “endometriosis and granulosa cells,” “phthalate and granulosa cells,” and “phthalates and endometrial cells.”. Results: Endometriosis can affect cytokine production, steroidogenesis, cell cycle progression, expression of estrogen receptor-α (ER-α)/progesterone receptor (PR), and cause endoplasmic reticulum stress, senescence, apoptosis, autophagy, and oxidative stress in the granulosa cells. Mono-n-butyl phthalate (MnBP) alters the expression of cytokines, cell cycle-associated genes, ovarian stimulation, steroidogenesis, and progesterone production. Several in vitro studies have demonstrated that phthalate caused inflammation, invasion, change in cytokines, increased oxidative stress, viability, resistance to hydrogen peroxide, and proliferation of endometrial cells. Conclusion: This might provide new insights about the impact of phthalate on the pathogenesis of endometriosis and its consequences on the ovarian function.
KW - endometrial cells
KW - endometriosis
KW - granulosa cells
KW - phthalate
KW - reproductive function
UR - http://www.scopus.com/inward/record.url?scp=85099238451&partnerID=8YFLogxK
U2 - 10.1002/rmb2.12364
DO - 10.1002/rmb2.12364
M3 - Review article
AN - SCOPUS:85099238451
SN - 1445-5781
VL - 20
SP - 159
EP - 168
JO - Reproductive Medicine and Biology
JF - Reproductive Medicine and Biology
IS - 2
ER -