The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Davor Pavlovic, David C.A. Neville, Olivier Argaud, Baruch Blumberg, Raymond A. Dwek, Wolfgang B. Fischer, Nicole Zitzmann*

*此作品的通信作者

研究成果: Article同行評審

312 引文 斯高帕斯(Scopus)

摘要

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

原文English
頁(從 - 到)6104-6108
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
100
發行號10
DOIs
出版狀態Published - 13 5月 2003

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