The fetal frontomaxillary facial angle in normal and trisomy 21 ultrasounds at 11-13+6 weeks of gestation: Findings among the ethnic Chinese compared with Caucasian

Ching Hua Hsiao, Wen Liang Liu, Ran Chou Chen, Bo Jen Cheng, Yin Jiun Tseng, Woei Chyn Chu*

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Objective: The aim of this research was to compare the fetal frontomaxillary facial (FMF) angle between normal and trisomy 21 fetuses at 11+0-13+6weeks gestation in a Chinese population. Methods: A prospective observational study was performed that included 640 euploid and 45 trisomy 21 singleton pregnancies undergoing first trimester ultrasound screening between 11 and 13+6weeks of gestation. The FMF angle was measured in the midsagittal plane using the standard technique. Results: The fetal mean FMF angle decreased with the increasing crown-rump length (CRL) from 88.6°at a CRL of 45mm to 78.5° at a CRL of 84mm (FMF angle=100.212-0.258×CRL, R2=0.222, p<0.001). The overall mean FMF angle in the euploid population was 82.9°±4.1° and in trisomy 21 cases, 92.3°±5.2°. Conclusions: Fetal FMF angle is affected by gestational age in a Chinese population, although it remains a significant predictor of fetal trisomy 21.

原文English
頁(從 - 到)711-715
頁數5
期刊Prenatal Diagnosis
33
發行號8
DOIs
出版狀態Published - 8月 2013

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