The effect of far-infrared therapy on the peritoneal expression of glucose degradation products in diabetic patients on peritoneal dialysis

Chia Ning Chang, Chih Yuan Niu, Ann Charis Tan, Chia Hao Chan, Chun Fan Chen, Tz Heng Chen, Szu Yuan Li, Yung Tai Chen, Fan Yu Chen, Wen Sheng Liu, Chih Ching Lin*, Guor Jien Wei

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Peritoneal dialysis (PD) is a treatment modality for end-stage renal disease (ESRD) pa-tients. Dextrose is a common osmotic agent used in PD solutions and its absorption may exacerbate diabetes mellitus, a common complication of ESRD. PD solutions also contain glucose degradation products (GDPs) that may lead to encapsulating peritoneal sclerosis (EPS), a severe complication of PD. A previous study showed that far-infrared (FIR) therapy improved a patient’s gastrointestinal symptoms due to EPS. Due to limited literature on the matter, this study aims to investigate dialy-sate GDPs and peritoneal function in diabetic patients on PD. Thirty-one PD patients were enrolled and underwent 40 min of FIR therapy twice daily for six months. We demonstrated the effect of FIR therapy on the following: (1) decrease of methylglyoxal (p = 0.02), furfural (p = 0.005), and 5-hy-droxymethylfurfural (p = 0.03), (2) increase of D/D0 glucose ratio (p = 0.03), and (3) decrease of po-tassium levels (p = 0.008) in both DM and non-DM patients, as well as (4) maintenance and increase of peritoneal Kt/V in DM and non-DM patients, respectively (p = 0.03). FIR therapy is a non-invasive intervention that can decrease dialysate GDPs in PD patients by improving peritoneal transport rate and solute removal clearance, while also maintaining dialysis adequacy.

原文English
文章編號3732
期刊International Journal Of Molecular Sciences
22
發行號7
DOIs
出版狀態Published - 1 4月 2021

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