Recently we are developing the cell-cell fusion platform which has a potential to modify cell behavior for degenerative diseases. We present a cell-cell pairing platform to trap and pair mobile HepG2 liver cells and 3T3 fibroblast cells. A 10μm×20μm metal electrode is placed precisely inside a lateral cavity. The lateral cavity design bends the electric field and enlarges the positive dielectrophoresis force. Besides, the structure provides a shelter function to diminish the damage of direct flow shear stress acting on trapped cells. Finally, we demonstrate the distinct liver and fibroblast cells pairing sequence for the future application of cell-cell fusion.