The disparities in the electrogram voltage measurement during atrial fibrillation and sinus rhythm

Chien Jung Chang, Yenn Jiang Lin, Satoshi Higa, Shih Lin Chang, Li Wei Lo, Ta Chuan Tuan, Yu Feng Hu, Ameya R. Udyavar, Wei Hua Tang, Wen Chin Tsai, Shin Yu Huang, Nguyen Huu Tung, Kazuyoshi Suenari, Hsuan Ming Tsao, Shih Ann Chen*


研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)


Unipolar Electrogram Voltage in Patients with Atrial Fibrillation. Introduction: The peak electrogram voltage is a typical metric applied at each site for voltage mapping. However, the peak amplitude depends on the direction and complexity of the wavefront propagation. The root-mean-square (RMS) measure of the amplitude is a temporal integral that represents the steady-state value. The objective of this study was to investigate the disparities between the electrogram voltage during SR and AF by using 2 recording modalities: the conventional peak voltage and an RMS measurement. Methods and Results: This study enrolled 20 patients (age = 59 ± 13) with paroxysmal AF undergoing catheter ablation guided by Ensite array. The unipolar electrogram voltage during SR and AF (7 seconds in duration) was obtained from the same sites, and labeled by the 3-dimensional (3D) geometry. Overall 1,200 electrograms were analyzed from equally distributed mapping sites in the left atrium. A point-by-point comparison of the unipolar peak negative voltage (PNV) showed less agreement (Bland and Altman test: 10.4% outside 2 standard deviations, and intraclass correlation coefficient ICC = 0.64). The RMS voltage demonstrated agreement between SR and AF for all sites (BA test: 5.9% of the sites, and the ICC = 0.81). The probability of predicting a low-voltage during AF using the voltage during SR was significantly lower when using the PNV measurement compared to that when using the RMS voltage (15% vs 61%, P < 0.05). Conclusion: The peak electrogram unipolar voltage during AF did not represent the voltage during SR. The RMS amplitude may be an alternative metric for voltage mapping to characterize the myocardial substrate. (J Cardiovasc Electrophysiol, Vol. 21, pp. 393-398, April 2010)

頁(從 - 到)393-398
期刊Journal of cardiovascular electrophysiology
出版狀態Published - 4月 2010


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