The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation

Shin Meng Deng, Chia Jung Chen, Hung Lung Lin, Irene H. Cheng*

*此作品的通信作者

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut–brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut–brain axis is a potential approach to delay AD progression.

原文English
頁(從 - 到)748-753
頁數6
期刊IUBMB Life
74
發行號8
DOIs
出版狀態Published - 8月 2022

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