The autophagic induction in helicobacter pylori-Infected macrophage

Ya Hui Wang, Jiunn Jong Wu, Huan Yao Lei*

*此作品的通信作者

研究成果: Article同行評審

81 引文 斯高帕斯(Scopus)

摘要

Helicobacter pylori has developed several mechanisms to evade the intracellular killing after phagocytosis. In this study, we reported that some Taiwanese clinical isolated H. pylori can multiply in human monocytic cells, such as THP-1 or U937 cells, but not in murine macrophage Raw264.7 cells. After internalization, there was a 5- to 10-fold increment of re-cultivable H. pylori from the infected THP-1 cells at 12 hrs post infection. The dividing H. pylori was found in a double-layer vesicle, which is characteristic of autophagosome. The formation of autophago-somes is associated with the multiplication of H. pylori in THP-1 cells. Its modulation with rapamycin or 3-MA affects the level of H. pylori replication. Furthermore, the VacA or CagA mutants of H. pylori have lower levels of multiplication in macrophages. We conclude that H. pylori infection induces autophagosome formation, and these autophagic vesicles were adapted for the multiplication of H. pylori in the host.

原文English
頁(從 - 到)171-180
頁數10
期刊Experimental Biology and Medicine
234
發行號2
DOIs
出版狀態Published - 2月 2009

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