TY - JOUR
T1 - The association between brain-derived neurotrophic factor and central pulse pressure after an oral glucose tolerance test
AU - Lee, I. Te
AU - Chen, Chen Huan
AU - Wang, Jun Sing
AU - Fu, Chia Po
AU - Lee, Wen Jane
AU - Liang, Kae Woei
AU - Lin, Shih Yi
AU - Sheu, Wayne Huey Herng
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/1
Y1 - 2018/1
N2 - Background Arterial stiffening blunts postprandial vasodilatation. We hypothesized that brain-derived neurotrophic factor (BDNF) may modulate postprandial central pulse pressure, a surrogate marker for arterial stiffening. Methods A total of 82 non-diabetic subjects received a 75-g oral glucose tolerance test (OGTT) after overnight fasting. Serum BDNF concentrations were determined at 0, 30, and 120 min to calculate the area under the curve (AUC). Brachial and central blood pressures were measured using a noninvasive central blood pressure monitor before blood withdrawals at 0 and 120 min. Results With the median AUC of BDNF of 45 (ng/ml) ∗ h as the cutoff value, the central pulse pressure after glucose intake was significantly higher in the subjects with a low BDNF than in those with a high BDNF (63 ± 16 vs. 53 ± 11 mm Hg, P = 0.003), while the brachial pulse pressure was not significantly different between the 2 groups (P = 0.099). In a multivariate linear regression model, a lower AUC of BDNF was an independent predictor of a higher central pulse pressure after oral glucose intake (linear regression coefficient − 0.202, 95% confidence interval − 0.340 to − 0.065, P = 0.004). Conclusion After oral glucose challenge, a lower serum BDNF response is significantly associated with a higher central pulse pressure.
AB - Background Arterial stiffening blunts postprandial vasodilatation. We hypothesized that brain-derived neurotrophic factor (BDNF) may modulate postprandial central pulse pressure, a surrogate marker for arterial stiffening. Methods A total of 82 non-diabetic subjects received a 75-g oral glucose tolerance test (OGTT) after overnight fasting. Serum BDNF concentrations were determined at 0, 30, and 120 min to calculate the area under the curve (AUC). Brachial and central blood pressures were measured using a noninvasive central blood pressure monitor before blood withdrawals at 0 and 120 min. Results With the median AUC of BDNF of 45 (ng/ml) ∗ h as the cutoff value, the central pulse pressure after glucose intake was significantly higher in the subjects with a low BDNF than in those with a high BDNF (63 ± 16 vs. 53 ± 11 mm Hg, P = 0.003), while the brachial pulse pressure was not significantly different between the 2 groups (P = 0.099). In a multivariate linear regression model, a lower AUC of BDNF was an independent predictor of a higher central pulse pressure after oral glucose intake (linear regression coefficient − 0.202, 95% confidence interval − 0.340 to − 0.065, P = 0.004). Conclusion After oral glucose challenge, a lower serum BDNF response is significantly associated with a higher central pulse pressure.
KW - Arterial stiffness
KW - Brain-derived neurotrophic factor
KW - Central pulse pressure
KW - Oral glucose tolerance test
UR - http://www.scopus.com/inward/record.url?scp=85033365879&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2017.10.023
DO - 10.1016/j.cca.2017.10.023
M3 - Article
C2 - 29080692
AN - SCOPUS:85033365879
SN - 0009-8981
VL - 476
SP - 1
EP - 8
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -