The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages

Ivan Dzhagalov, Ashley St. John, You Wen He*

*此作品的通信作者

研究成果: Article同行評審

227 引文 斯高帕斯(Scopus)

摘要

The antiapoptotic protein Mcl-1, a member of the Bcl-2 family, plays critical roles in promoting the survival of lymphocytes and hematopoietic stem cells. Although previous studies have implicated Mcl-1 in regulating the survival of neutrophils and macrophages, the in vivo function of Mcl-1 in these 2 cell lineages remained unclear. To address this, we have generated mice conditionally lacking Mcl-1 expression in neutrophils and macrophages. We show that Mcl-1 conditional knockout mice had a severe defect in neutrophil survival, whereas macrophage survival was normal. The granulocyte compartment in the blood, spleen, and bone marrow of Mcl-1 conditional knockout mice exhibited an approximately 2- to 3-fold higher apoptotic rate than control cells. In contrast, resting and activated macrophages from Mcl-1-deficient mice exhibited normal survival and contained up-regulated expression of Bcl-2 and Bcl-x L. These data suggest that Mcl-1 plays a nonredundant role in promoting the survival of neutrophils but not macrophages.

原文English
頁(從 - 到)1620-1626
頁數7
期刊Blood
109
發行號4
DOIs
出版狀態Published - 15 2月 2007

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