Targeting post-translational modifications of histones for cancer therapy

Y. C. Hsu, Y. H. Hsieh, C. C. Liao, L. W. Chong, C. Y. Lee, Yung Luen Yu*, Ruey Hwang Chou

*此作品的通信作者

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

Post-translational modifications (PTMs) on histones including acetylation, methylation, phosphorylation, citrullination, ubiquitination, ADP ribosylation, and sumoylation, play important roles in different biological events including chromatin dynamics, DNA replication, and transcriptional regulation. Aberrant histones PTMs leads to abnormal gene expression and uncontrolled cell proliferation, followed by development of cancers. Therefore, targeting the enzymes required for specific histone PTMs holds a lot of potential for cancer treatment. In this review article, we retrospect the latest studies in the regulations of acetylation, methylation, and phosphorylation of histones. We also summarize inhibitors/drugs that target these modifications for cancer treatment.

原文English
頁(從 - 到)69-84
頁數16
期刊Cellular and Molecular Biology
61
發行號6
DOIs
出版狀態Published - 2015

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