Targeted delivery systems for oligonucleotide therapeutics

Bo Yu, Xiaobin Zhao, James L. Lee, Robert J. Lee*

*此作品的通信作者

研究成果: Review article同行評審

126 引文 斯高帕斯(Scopus)

摘要

Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery. Meanwhile, an effective delivery system must successfully overcome a multitude of biological barriers to enable the oligonucleotides to reach the site of action and access their biological targets. Several delivery strategies based on different platform technologies and different targeting ligands have been developed to achieve these objectives. This review aims at providing a summary and perspective on recent progress in this very active area of research.

原文English
頁(從 - 到)195-203
頁數9
期刊AAPS Journal
11
發行號1
DOIs
出版狀態Published - 3月 2009

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