Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease

Ya Ling Yang; Cheng Hsueh Wu; Pai Feng Hsu; Su Chan Chen; Shao Sung Huang; Wan Leong Chan; Shing Jong Lin; Chia Yu Chou; Jaw Wen Chen; Ju Pin Pan; Min Ji Charng; Ying Hwa Chen; Tao Cheng Wu; Tse Min Lu; Po Hsun Huang; Hao Min Cheng; Chin Chou Huang; Shih Hsien Sung; Yenn Jiang Lin; Hsin Bang Leu

doi:10.1111/eci.13230

Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease

Ya Ling Yang, Cheng Hsueh Wu, Pai Feng Hsu, Su Chan Chen, Shao Sung Huang, Wan Leong Chan, Shing Jong Lin, Chia Yu Chou, Jaw Wen Chen, Ju Pin Pan, Min Ji Charng, Ying Hwa Chen, Tao Cheng Wu, Tse Min Lu, Po Hsun Huang, Hao Min Cheng, Chin Chou Huang, Shih Hsien Sung, Yenn Jiang Lin, Hsin Bang Leu^*

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研究成果: Article › 同行評審

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摘要

Background: This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. Methods: A total of 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. They were divided into two groups by baseline SII score (high SII vs low SII) to analyse the relationship between SII groups and the long-term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure. Results: An optimal SII cut-off point of 694.3 × 10⁹ was identified for MACE in the CAD training cohort (n = 373) and then verified in the second larger CAD cohort (n = 5602). Univariate and multivariate analyses showed that a higher SII score (≥694.3) was independently associated with increased risk of developing cardiac death (HR: 2.02; 95% CI: 1.43-2.86), nonfatal MI (HR: 1.42; 95% CI: 1.09-1.85), nonfatal stroke (HR: 1.96; 95% CI: 1.28-2.99), MACE (HR: 1.65; 95% CI: 1.36-2.01) and total major events (HR: 1.53; 95% CI: 1.32-1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C-index (P <.001) and reclassification risk categories by significant NRI (P <.05) and IDI (P <.05). Conclusions: SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.

原文	English
文章編號	e13230
期刊	European Journal of Clinical Investigation
卷	50
發行號	5
DOIs	https://doi.org/10.1111/eci.13230
出版狀態	Published - 1 5月 2020

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Yang, Y. L., Wu, C. H., Hsu, P. F., Chen, S. C., Huang, S. S., Chan, W. L., Lin, S. J., Chou, C. Y., Chen, J. W., Pan, J. P., Charng, M. J., Chen, Y. H., Wu, T. C., Lu, T. M., Huang, P. H., Cheng, H. M., Huang, C. C., Sung, S. H., Lin, Y. J., & Leu, H. B. (2020). Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. European Journal of Clinical Investigation, 50(5), 文章 e13230. https://doi.org/10.1111/eci.13230

@article{6247073980074416b204f067a47e6573,

title = "Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease",

abstract = "Background: This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. Methods: A total of 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. They were divided into two groups by baseline SII score (high SII vs low SII) to analyse the relationship between SII groups and the long-term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure. Results: An optimal SII cut-off point of 694.3 × 109 was identified for MACE in the CAD training cohort (n = 373) and then verified in the second larger CAD cohort (n = 5602). Univariate and multivariate analyses showed that a higher SII score (≥694.3) was independently associated with increased risk of developing cardiac death (HR: 2.02; 95% CI: 1.43-2.86), nonfatal MI (HR: 1.42; 95% CI: 1.09-1.85), nonfatal stroke (HR: 1.96; 95% CI: 1.28-2.99), MACE (HR: 1.65; 95% CI: 1.36-2.01) and total major events (HR: 1.53; 95% CI: 1.32-1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C-index (P <.001) and reclassification risk categories by significant NRI (P <.05) and IDI (P <.05). Conclusions: SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.",

keywords = "coronary artery disease, inflammation, percutaneous coronary intervention",

author = "Yang, {Ya Ling} and Wu, {Cheng Hsueh} and Hsu, {Pai Feng} and Chen, {Su Chan} and Huang, {Shao Sung} and Chan, {Wan Leong} and Lin, {Shing Jong} and Chou, {Chia Yu} and Chen, {Jaw Wen} and Pan, {Ju Pin} and Charng, {Min Ji} and Chen, {Ying Hwa} and Wu, {Tao Cheng} and Lu, {Tse Min} and Huang, {Po Hsun} and Cheng, {Hao Min} and Huang, {Chin Chou} and Sung, {Shih Hsien} and Lin, {Yenn Jiang} and Leu, {Hsin Bang}",

note = "Publisher Copyright: {\textcopyright} 2020 Stichting European Society for Clinical Investigation Journal Foundation",

year = "2020",

month = may,

day = "1",

doi = "10.1111/eci.13230",

language = "English",

volume = "50",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

}

Yang, YL, Wu, CH, Hsu, PF, Chen, SC, Huang, SS, Chan, WL, Lin, SJ, Chou, CY, Chen, JW, Pan, JP, Charng, MJ, Chen, YH, Wu, TC, Lu, TM, Huang, PH , Cheng, HM, Huang, CC, Sung, SH , Lin, YJ & Leu, HB 2020, 'Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease', European Journal of Clinical Investigation, 卷 50, 編號 5, e13230. https://doi.org/10.1111/eci.13230

TY - JOUR

T1 - Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease

AU - Yang, Ya Ling

AU - Wu, Cheng Hsueh

AU - Hsu, Pai Feng

AU - Chen, Su Chan

AU - Huang, Shao Sung

AU - Chan, Wan Leong

AU - Lin, Shing Jong

AU - Chou, Chia Yu

AU - Chen, Jaw Wen

AU - Pan, Ju Pin

AU - Charng, Min Ji

AU - Chen, Ying Hwa

AU - Wu, Tao Cheng

AU - Lu, Tse Min

AU - Huang, Po Hsun

AU - Cheng, Hao Min

AU - Huang, Chin Chou

AU - Sung, Shih Hsien

AU - Lin, Yenn Jiang

AU - Leu, Hsin Bang

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Background: This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. Methods: A total of 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. They were divided into two groups by baseline SII score (high SII vs low SII) to analyse the relationship between SII groups and the long-term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure. Results: An optimal SII cut-off point of 694.3 × 109 was identified for MACE in the CAD training cohort (n = 373) and then verified in the second larger CAD cohort (n = 5602). Univariate and multivariate analyses showed that a higher SII score (≥694.3) was independently associated with increased risk of developing cardiac death (HR: 2.02; 95% CI: 1.43-2.86), nonfatal MI (HR: 1.42; 95% CI: 1.09-1.85), nonfatal stroke (HR: 1.96; 95% CI: 1.28-2.99), MACE (HR: 1.65; 95% CI: 1.36-2.01) and total major events (HR: 1.53; 95% CI: 1.32-1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C-index (P <.001) and reclassification risk categories by significant NRI (P <.05) and IDI (P <.05). Conclusions: SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.

AB - Background: This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. Methods: A total of 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. They were divided into two groups by baseline SII score (high SII vs low SII) to analyse the relationship between SII groups and the long-term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure. Results: An optimal SII cut-off point of 694.3 × 109 was identified for MACE in the CAD training cohort (n = 373) and then verified in the second larger CAD cohort (n = 5602). Univariate and multivariate analyses showed that a higher SII score (≥694.3) was independently associated with increased risk of developing cardiac death (HR: 2.02; 95% CI: 1.43-2.86), nonfatal MI (HR: 1.42; 95% CI: 1.09-1.85), nonfatal stroke (HR: 1.96; 95% CI: 1.28-2.99), MACE (HR: 1.65; 95% CI: 1.36-2.01) and total major events (HR: 1.53; 95% CI: 1.32-1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C-index (P <.001) and reclassification risk categories by significant NRI (P <.05) and IDI (P <.05). Conclusions: SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.

KW - coronary artery disease

KW - inflammation

KW - percutaneous coronary intervention

UR - http://www.scopus.com/inward/record.url?scp=85084430798&partnerID=8YFLogxK

U2 - 10.1111/eci.13230

DO - 10.1111/eci.13230

M3 - Article

C2 - 32291748

AN - SCOPUS:85084430798

SN - 0014-2972

VL - 50

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 5

M1 - e13230

ER -

Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease

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