Synthesis, surface modification, and photophysical studies of Ln2O2S:Ln'3+ (Ln=Gd, Tb, Eu; Ln'=Tb and/ or Eu) nanoparticles for luminescence bioimaging

Syue Liang Lin, Tse Ying Liu, Chun Liang Lo, Bo Sheng Wang, Yi Jang Lee, Kai Ying Lin, C. Allen Chang*

*此作品的通信作者

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

It has been demonstrated that by using doping and co-doping strategies the lifetimes as well as luminescence intensities of the doping species in the lanthanide oxysulfide nanoparticles (NPs) Ln2O2S:Ln'3+ (Ln=Gd, Tb, Eu; Ln'=Tb, Eu, 1% and 5%) could be tuned. The lanthanide oxysulfide NPs, i.e., Gd2O2S, Tb2O2S and Gd2O2S:Tb3+(5%) were synthesized as matrices and doped with Eu3+(1% or 5%), by the thermal decomposition method and characterized by TEM, XRD, photoluminescence, cellular and in vivo animal imaging studies for potential luminescence bioimaging applications. Of these materials, Gd2O2S:Eu3+(5%) NPs possess the highest photo-stability and strongest luminescent intensity at 625 nm with a lifetime 853 μs in hexane. Surface modification of the Gd2O2S:Eu3+(5%) NPs with mPEG-APTES to increase its aqueous solubility resulted in almost complete luminescence quenching. Calcination of the host Gd2O2S:Eu3+(5%) NPs at 400 °C to increase their crystallinity and maintained some of their luminescence properties in aqueous solution. Further surface modification of the Gd2O2S:Eu3+(5%)-APTES NPs with mPEG and Alexa Fluor 660 allowed their effective cellular and in vivo animal luminescence imaging with low bio-toxicity. These novel imaging materials with tunable lifetimes would be potentially useful for luminescence bioimaging applications, particularly in the time-resolved, up-conversion, and/or multiplex modes.

原文English
頁(從 - 到)165-175
頁數11
期刊Journal of Luminescence
175
DOIs
出版狀態Published - 1 7月 2016

指紋

深入研究「Synthesis, surface modification, and photophysical studies of Ln2O2S:Ln'3+ (Ln=Gd, Tb, Eu; Ln'=Tb and/ or Eu) nanoparticles for luminescence bioimaging」主題。共同形成了獨特的指紋。

引用此