Synthesis of some N,N″-bis(amide) derivatives of diethylenetriaminepentaacetic acid and the stabilities of their complexes with Gd3+, Ca2+, Cu2+ and Zn2+

Yun-Ming Wang*, Tsann Hwang Cheng, Gin Chung Liu, Reu Sheng Sheu

*此作品的通信作者

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

Three N,N″-bis(amide) derivatives of H5dtpa (diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid), H3L1 = bis-(isopropylamide), H3L2 = bis(tert-butylamide) and H3L3 = bis(benzylamide), were synthesized. Their protonation constants were determined by potentiometric titration in 0.10 mol dm-3 KCl and by NMR pH titration at 25 ± 0.1°C. Stability and selectivity constants were measured to evaluate the possibility of using the corresponding gadolinium(III) complexes as magnetic resonance imaging contrast agents. The formation of the gadolinium(III), copper(II), zinc(II) and calcium(II) complexes were investigated quantitatively by potentiometry. The stability constant determined for GdIII is larger than those for CaII, ZnII and CuII for these octadentate ligands. The selectivity constants and modified selectivity constants of the amides for Gd3t over endogenously available metal ions were calculated.

原文English
頁(從 - 到)833-837
頁數5
期刊Journal of the Chemical Society - Dalton Transactions
發行號5
DOIs
出版狀態Published - 7 3月 1997

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