@article{1245d1b067d145c3986583b5e8fc152f,
title = "Synthesis of Aminofuran-Linked Benzimidazoles and Cyanopyrrole-Fused Benzimidazoles by Condition-Based Skeletal Divergence",
abstract = "A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, while the same reaction afforded 3-cyano-benzopyrrolo-imidazoles under microwave irradiation. Two nonequivalent nucleophilic centers on benzimidazole moiety were manipulated elegantly by different reaction conditions to achieve the skeletal diversity.",
keywords = "2-aminofuranyl-benzimidazole, 3-cyano-benzopyrrolo-imidazole, divergent synthesis, nonequivalent nucleophilicity, skeletal diversity",
author = "Hsu, {Wei Shun} and Tsai, {Min Huan} and Barve, {Indrajeet J.} and Yellol, {Gorakh S.} and Chung-Ming Sun",
note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = jul,
day = "10",
doi = "10.1021/acscombsci.7b00052",
language = "English",
volume = "19",
pages = "492--499",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "American Chemical Society",
number = "7",
}