Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

Chien Hung Lin, Tsung Che Chang, Anindya Das, Ming Yu Fang, Hui Chen Hung, Kai Cheng Hsu, Jinn-Moon Yang, Mark Von Itzstein, Kwok-Kong Mong, Tsu An Hsu*, Chun Cheng Lin

*此作品的通信作者

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.

原文English
頁(從 - 到)3943-3948
頁數6
期刊Organic and Biomolecular Chemistry
11
發行號24
DOIs
出版狀態Published - 28 六月 2013

指紋

深入研究「Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities」主題。共同形成了獨特的指紋。

引用此