TY - JOUR
T1 - Synthesis of 4,4-Difluoroalkenes by Coupling of α-Substituted α,α-Difluoromethyl Halides with Allyl Sulfones under Photoredox Catalyzed Conditions
AU - Uno, Misae
AU - Sumino, Shuhei
AU - Fukuyama, Takahide
AU - Matsuura, Makoto
AU - Kuroki, Yoshichika
AU - Kishikawa, Yosuke
AU - Ryu, Ilhyong
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/7/2
Y1 - 2019/7/2
N2 - Photoredox-catalyzed allylation of α-gem-difluorinated organohalides with allyl sulfones proceeded smoothly under visible light irradiation to give 4,4-difluoroalkenes in good yields. In the presence of catalytic Ru(bpy)3Cl2, Hantzsch ester, and diisopropylethylamine, the reaction was complete within 2 h. Using the same methodology, three-component cascade reactions to give 6,6-difluoroalkenes were carried out successfully.
AB - Photoredox-catalyzed allylation of α-gem-difluorinated organohalides with allyl sulfones proceeded smoothly under visible light irradiation to give 4,4-difluoroalkenes in good yields. In the presence of catalytic Ru(bpy)3Cl2, Hantzsch ester, and diisopropylethylamine, the reaction was complete within 2 h. Using the same methodology, three-component cascade reactions to give 6,6-difluoroalkenes were carried out successfully.
UR - http://www.scopus.com/inward/record.url?scp=85070118502&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.9b00901
DO - 10.1021/acs.joc.9b00901
M3 - Article
C2 - 31265292
AN - SCOPUS:85070118502
SN - 0022-3263
VL - 84
SP - 9330
EP - 9338
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 14
ER -