Synthesis of 2-(pyridylvinyl)chromen-4-ones and their N-oxide analogs for assessment of their biological activities as anticancer agents

Yu Chun Ding, Yi Cheng Chu, Chuan Hsin Chang, Jia Hua Liang, Jih Jung Chen*, Tzenge Lien Shih*

*此作品的通信作者

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摘要

2-Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2-styrylchromones with a nitrogen atom in the benzene rings forms 2-(pyridylvinyl)chromen-4-ones (aza-2-styrylchromones). We have synthesized a series of novel 2-(pyridylvinyl)chromen-4-ones and their pyridine N-oxides to evaluate them as potential anticancer agents against human non-small-cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5-fluorouracil and showed no toxicity against normal cells.

原文English
文章編號2300445
期刊Archiv der Pharmazie
357
發行號4
DOIs
出版狀態Published - 4月 2024

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