TY - JOUR
T1 - Surface modification of nanoporous poly(ε-caprolactone) membrane with poly(ethylene glycol) to prevent biofouling
T2 - Part II. Effects of graft density and chain length
AU - Yen, Chi
AU - He, Hongyan
AU - Fei, Zhengzheng
AU - Zhang, Xulang
AU - Lee, L. James
AU - Ho, W. S.Winston
N1 - Funding Information:
1William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, United States 2NSF Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices, The Ohio State University, Columbus, Ohio, United States 3Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio, United States Biofouling is a common problem in wastewater treatments and medical devices. It is important to find a strategy to prevent biofouling and surface modification. This study presents a novel approach to modifying the surface of nanoporous poly(ε-caprolactone) membrane with poly(ethylene glycol) (PEG) to prevent biofouling problems. Oxygen Received 11 March 2010. We would like to thank the National Science Foundation–sponsored Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices (NSEC-CANPBD) at the Ohio State University for the financial support of this work. Address correspondence to W. S. Winston Ho, Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH 43210-1178, United States. E-mail: [email protected]
PY - 2010/11
Y1 - 2010/11
N2 - Biofouling is a common problem in wastewater treatments and medical devices. It is important to find a strategy to prevent biofouling and surface modification. This study presents a novel approach to modifying the surface of nanoporous poly(-caprolactone) membrane with poly(ethylene glycol) (PEG) to prevent biofouling problems. Oxygen plasma and poly(ethylene glycol)-monoacrylates (PEGMAs) were utilized in the surface modification process. Mouse embryonic fibroblast was used as a model biofoulant. The effects of the density and length of PEG chains on surface properties and cell adhesion were investigated. Contact angle measurements and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectra illustrated that PEG can be successfully immobilized on the membrane surface. Membranes which were pre-treated with higher PEG concentrations can lead to higher grafting density and greater resistance against cell adhesion. The resistance against cell adhesion cannot be enhanced while the PEG concentration is higher than a certain point, i.e., 0.1M. For different chain lengths, PEG(400)MA can provide higher resistance to cell adhesion than PEG(200)MA and PEG(1000)MA.
AB - Biofouling is a common problem in wastewater treatments and medical devices. It is important to find a strategy to prevent biofouling and surface modification. This study presents a novel approach to modifying the surface of nanoporous poly(-caprolactone) membrane with poly(ethylene glycol) (PEG) to prevent biofouling problems. Oxygen plasma and poly(ethylene glycol)-monoacrylates (PEGMAs) were utilized in the surface modification process. Mouse embryonic fibroblast was used as a model biofoulant. The effects of the density and length of PEG chains on surface properties and cell adhesion were investigated. Contact angle measurements and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectra illustrated that PEG can be successfully immobilized on the membrane surface. Membranes which were pre-treated with higher PEG concentrations can lead to higher grafting density and greater resistance against cell adhesion. The resistance against cell adhesion cannot be enhanced while the PEG concentration is higher than a certain point, i.e., 0.1M. For different chain lengths, PEG(400)MA can provide higher resistance to cell adhesion than PEG(200)MA and PEG(1000)MA.
KW - chain length
KW - graft density
KW - oxygen plasma
KW - poly(ethylene glycol)
KW - polycaprolactone (PCL) membrane
UR - http://www.scopus.com/inward/record.url?scp=77957260090&partnerID=8YFLogxK
U2 - 10.1080/00914037.2010.504164
DO - 10.1080/00914037.2010.504164
M3 - Article
AN - SCOPUS:77957260090
SN - 0091-4037
VL - 59
SP - 943
EP - 957
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 11
ER -