Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Chiao Wen Chen; Ching Chi Wang; Xin Ru Li; Henryk Witek; Kwok Kong Tony Mong

doi:10.1039/d0ob00252f

Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Chiao Wen Chen, Ching Chi Wang, Xin Ru Li, Henryk Witek, Kwok Kong Tony Mong^*

^*此作品的通信作者

研究成果: Article › 同行評審

6 引文斯高帕斯（Scopus）

摘要

In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.

原文	English
頁（從 - 到）	3135-3141
頁數	7
期刊	Organic and Biomolecular Chemistry
卷	18
發行號	16
DOIs	https://doi.org/10.1039/d0ob00252f
出版狀態	Published - 28 4月 2020

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10.1039/d0ob00252f

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abstract = "In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.",

author = "Chen, {Chiao Wen} and Wang, {Ching Chi} and Li, {Xin Ru} and Henryk Witek and Mong, {Kwok Kong Tony}",

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T1 - Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

AU - Chen, Chiao Wen

AU - Wang, Ching Chi

AU - Li, Xin Ru

AU - Witek, Henryk

AU - Mong, Kwok Kong Tony

PY - 2020/4/28

Y1 - 2020/4/28

N2 - In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.

AB - In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.

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U2 - 10.1039/d0ob00252f

DO - 10.1039/d0ob00252f

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AN - SCOPUS:85084167665

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VL - 18

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EP - 3141

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 16

ER -

Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

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