Study on the Influence of Microinjection Molding Processing Parameters on Replication Quality of Polylactic Acid Microneedle Array Product

Wenqian Yu, Junfeng Gu, Zheng Li, Shilun Ruan, Biaosong Chen, Changyu Shen, Ly James Lee, Xinyu Wang*

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Biodegradable microneedles with a drug delivery channel have enormous potential for consumers, including use in chronic disease, vaccines, and beauty applications, due to being painless and scarless. This study designed a microinjection mold to fabricate a biodegradable polylactic acid (PLA) in-plane microneedle array product. In order to ensure that the microcavities could be well filled before production, the influences of the processing parameters on the filling fraction were investigated. The results indicated that the PLA microneedle can be filled under fast filling, higher melt temperature, higher mold temperature, and higher packing pressure, although the dimensions of the microcavities were much smaller than the base portion. We also observed that the side microcavities filled better than the central ones under certain processing parameters. However, this does not mean that the side microcavities filled better than the central ones. The central microcavity was filled when the side microcavities were not, under certain conditions in this study. The final filling fraction was determined by the combination of all parameters, according to the analysis of a 16 orthogonal latin hypercube sampling analysis. This analysis also showed the distribution in any two-parameter space as to whether the product was filled entirely or not. Finally, the microneedle array product was fabricated according to the investigation in this study.

原文English
文章編號1199
期刊Polymers
15
發行號5
DOIs
出版狀態Published - 3月 2023

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