Study on properties of near-infrared excitation upconversion nanoparticles for optogenetic applications

Tai Ling Huang, Wei Che Li, Jen Hsuan Wang, Chia Yen Lee, Ching-Cheng Chuang, Jung-Chih Chen

研究成果: Conference article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted great attention for biomedical applications due to good biocompatibility and unique anti-Stokes optical property. Channelrhodopsin-2 (ChR2) was used to change membrane potential that can triggered by blue light. However, blue light can't penetrate human tissue directly. For purpose of controlling the cardiomyocytes to produce depolarization after ChR2 gene transfer. In this study, UCNP were used co-precipitation method to synthesis which convert near-infrared (MR) into visible emission. In order to confirm the effect between the UCNP and ChR2 transgene in cardiomyocyte, we recorded preliminary membrane potential results by high speed camera. These results demonstrated that UCNP extended elongation of membrane potential under NIR excitation indeed. It showed that UCNP we prepared can be applied to cardiac optogenetics.

原文English
文章編號1114001-217
期刊Proceedings of SPIE - The International Society for Optical Engineering
11140
出版狀態Published - 1 1月 2019
事件Biomedical Imaging and Sensing Conference 2019, BISC 2019 - Yokohama, Japan
持續時間: 22 4月 201926 4月 2019

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