TY - GEN
T1 - Study of protoporphyrin IX-loaded silica hollow spheres for photodynamic therapy
AU - Tseng, Guo Huan
AU - Liu, Tse-Ying
PY - 2013/5/12
Y1 - 2013/5/12
N2 - The PpIX-loaded silica hollow spheres were fabricated using DMDES (dimethyldiethoxysilane) which could be transformed into PDMS (polydimethylsiloxane) templates [1], and TEOS (tetraethoxysilane) as crosslinker. The morphology of the resulting samples was observed using transmission electron microscopy (TEM), and a hollow structure was clearly observed. The PpIX-containing silica structure was confirmed using fourier-transform infrared spectroscopy (FTIR). The FTIR peak around 1030 cm'1 was assigned to the characteristic peak of silica, indicated the shell was formed by silica. The singlet oxygen generation ability of the sample was confirmed using UV-Visible (UV-VIS) spectroscopy and singlet oxygen probe (DPA, diphenyl anthracene). After combined with singlet oxygen, the photo absorption of DPA at 376 nm would decrease. The resulting UV-VIS spectrum suggested that PpIX loaded in silica hollow spheres still generated singlet oxygen after UV irradiation [2].
AB - The PpIX-loaded silica hollow spheres were fabricated using DMDES (dimethyldiethoxysilane) which could be transformed into PDMS (polydimethylsiloxane) templates [1], and TEOS (tetraethoxysilane) as crosslinker. The morphology of the resulting samples was observed using transmission electron microscopy (TEM), and a hollow structure was clearly observed. The PpIX-containing silica structure was confirmed using fourier-transform infrared spectroscopy (FTIR). The FTIR peak around 1030 cm'1 was assigned to the characteristic peak of silica, indicated the shell was formed by silica. The singlet oxygen generation ability of the sample was confirmed using UV-Visible (UV-VIS) spectroscopy and singlet oxygen probe (DPA, diphenyl anthracene). After combined with singlet oxygen, the photo absorption of DPA at 376 nm would decrease. The resulting UV-VIS spectrum suggested that PpIX loaded in silica hollow spheres still generated singlet oxygen after UV irradiation [2].
KW - Photodynamic therapy
KW - Protoporphyrin IX
KW - Silica hollow sphere
UR - http://www.scopus.com/inward/record.url?scp=84881114333&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84881114333
SN - 9781482205862
T3 - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
SP - 266
EP - 269
BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Y2 - 12 May 2013 through 16 May 2013
ER -