Chloride (Cl-) channels are membrane proteins that consist of Cl- permeation pores capable of transporting Cl- ions across lipid membranes. In doing so, they play many important roles in maintaining the physiological functions of various cells, and malfunction of these membrane proteins leads to a variety of hereditary diseases, such as epilepsy, myotonia, and cystic fibrosis. Various types of Cl- channels have been identified with different structures and functions. This chapter discusses the structures and mechanisms of two specific types of Cl- channels - CLC Cl- channels and CFTR Cl- channels. Because homologous molecules of these two types of Cl- channels can function as transporters, the transporter mechanisms related to the functions of Cl- channels are also discussed.
|出版狀態||Published - 2012|