Structure-based mutational analysis of the hepatitis C virus NS3 helicase

Keyphrases

• Mutational Analysis 100%
• Hepatitis C Virus 100%
• ATP Synthase 100%
• Helicase 100%
• Nsp3 100%
• Helicase Activity 60%
• RNA Binding 40%
• Gatekeepers 40%
• Mutant Protein 20%
• Therapeutic Agents 20%
• Enzymatic Activity 20%
• Low Threshold 20%
• Drug Target 20%
• Functional Role 20%
• Anti-hepatitis C Virus 20%
• Per Se 20%
• RNA Helicase 20%
• Microenvironment 20%
• Carboxyl Terminus 20%
• Walker A Motif 20%
• ATP Hydrolysis 20%
• Threshold Level 20%
• Conserved Sequence 20%
• Helicase Domain 20%
• RNA-RNA 20%
• RNA-binding Activity 20%
• RNA Unwinding 20%
• Unwinding Phenomenon 20%
• Walker B Motif 20%
• ATP-dependent RNA Helicase 20%

Biochemistry, Genetics and Molecular Biology

• Hepatitis C Virus 100%
• Helicase 100%
• ATPase 83%
• RNA Binding 50%
• Adenosine Triphosphate 33%
• RNA Helicase 33%
• Arginine 33%
• Mutant Protein 16%
• Enzyme Activity 16%
• Enzymatic Hydrolysis 16%
• C-Terminus 16%
• Crystal Structure 16%
• Drug Targeting 16%
• Binding Affinity 16%
• RNA 16%
• Conserved Sequence 16%
• Sequence Motif 16%

Immunology and Microbiology

• Hepatitis C Virus 100%
• RNA Binding 75%
• Drug Targeting 25%
• Crystal Structure 25%
• Enzyme Activity 25%
• Binding Affinity 25%
• Carboxy Terminal Sequence 25%
• Conserved Sequence 25%